Pre-configured System

Atlas HD Crystallization

Allows crystallization processes to be monitored and controlled, as well as performing sonocrystallization or sonomilling techniques.

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Applications

This product is suitable for the following applications.

At a glance

The Atlas HD Crystallization system allows turbidity to be monitored and modified by controlling temperature and/or additions to the vessel. Real-time data is displayed on the Atlas HD touch screen and can be plotted in real time using the software.

The proprietary ultrasound technology with novel transducer based design, allows reproducible control of crystallizations, enabling selectivity of parameters such as particle size, shape, crystallinity, and polymorphism.

Monitor your crystallization using the Atlas turbidity probe and node and control the process using the innovative SonoLab module to perform sonocrystallization or sonomilling techniques.

  • Real-time data displayed & plotted on Atlas HD touch screen
  • Reproducible control of crystallizations

Dimensions

 

Smallest vessel: 108cm H x 54cm W x 45cm D
Largest vessel: 115cm H x 58cm W x 45cm D
Power: 100-240 VAC, 50/60 Hz, 5A Fuse

1. Controlled crystallization using sonocrystallization techniques

Sonocrystallization is the application of high intensity, low frequency ultrasound to your process, resulting in acoustic cavitation of the solution. Controlled cavitation allows extremely accurate control of nucleation, a process which is random and very difficult to control by conventional techniques.  The Atlas HD Crystallization system combines the powerful Atlas HD Potassium with a proprietary ultrasonic flow cell, generator and recirculating pump which can help you control the nucleation and growth of your crystallization process.

Syrris Atlas HD Crystallization System
Syrris Atlas HD Crystallization Reactor Key Feature - Crystals

2. Exact control of cooling and anti-solvent crystallization

The system can provide excellent control whether performing controlled cooling or anti-solvent crystallization.  Either using the base unit or PC software, the system contains sophisticated algorithms for precise temperature control ensuring that the process can be maintained within the metastable zone.  Anti-solvent crystallization is performed using the Atlas syringe pump which offers precise dosing from 1 μL/min to 10 mL/min.

 

Syrris Atlas HD chemist using Syringe Pump

3. Unrivalled automation

The Atlas HD Crystallization system has an intuitive touch screen control base, delivering unmatched capability to define and monitor proces conditions over a broad range of  working volumes.  The touch screen allows you to change parameters such as stirring, heating and dosing in real time and displays all data in a graphical way.  Further automation can be provided using PC software for complete crystallization control.

Syrris Atlas HD with Syringe Pump, chemist using touchscreen
Syrris Atlas HD Crystallization System in the lab

4. Narrow particle size distribution

Initiating nucleation using ultrasound offers reproducible crystallization.  The crystal growth can also be controlled with ultrasonic energy providing a very uniform and narrow particle size distribution.  Once crystals are formed, the system is in sonomilling mode and varying the intensity of the ultrasound, allows you to tailor the particle to your desired size.  Third party particle size monitors can also be integrated into the Atlas HD system ensuring that the platform provides all you need to master your crystallization

Syrris Atlas HD Crystallization System including the Prosonix Sonolab

What our customers say

Atlas HD reactor systems ensure each experiment is performed in exactly the same way every time.”

Scott Clunas, Process Chemist, TauRx Therapeutics, Aberdeen, UK
Scott Clunas, Process Chemist, TauRx Therapeutics, Aberdeen, UK

Specifications

Vessel Volume Range 50 mL, 100 mL, 250 mL, 500 mL, 1 L, 2 L (DN80), 1 L, 2 L, and 5 L (DN150)
Vessel Shapes Torispherical, Conical, Round Bottom
Vessel Profiles Jacketed, Vacuum Jacketed
Other Vessel Types No (Round Bottom Flasks Available with Regular Atlas Base)
Temperature Range -90°C to 250°C (with suitable seal kit)
Stirring Options Scorpion Overhead Stirrer (up to 800rpm/11Ncm torque), High Speed Available, High Torque Available
Automation Yes – using Atlas PC Software
Modes of Operation Atlas HD Touch Screen Control, Atlas PC Software, Manual Operation
Sensor Options Temperature, pH, Pressure, Turbidity, In-situ FTIR, Other Sensors Available
Pressure Range Vacuum (50mbar) to 0.5 Bar, See Atlas 200 Bar Pressure Systems for High Pressure up to 200 Bar, See Atlas 3 Bar Pressure Systems for High Pressure up to 3 Bar
Reaction Calorimetry Ability to Upgrade to Reaction Calorimetry, See Atlas HD Calorimeter
Reagent Addition and Sampling Manual Dosing, Automated Dosing (Volumetric), Automated Dosing (Gravimetric), Sampling of Liquids, Full Gas Control, Atlas Syringe Pump Range
Syrris Atlas HD Crystallization System close-up
A photograph of the Atlas Scorpion Overhead Stirrer Motor
Syrris Atlas HD Ice
Close-up of the Prosonix Sonolab as part of the Syrris Atlas HD Crystallization System

What we say

When performing crystallization reactions, the ability to quickly record data is critical. Atlas HD enables this at the touch of a button.”

Dr. Stephen Heffernan, Product Manager, Batch chemistry at Syrris
Dr. Stephen Heffernan, Product Manager, Batch chemistry at Syrris

Modules

  1. Base units

    • Atlas HD Potassium

      (included)

      The Atlas HD Potassium is the base reactor system on which all Atlas HD systems are built, and can be […]

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  2. Probes and Nodes

    • Turbidity Probe and Node

      (included)

      Accurate measurement and monitoring of turbidity in partnership with the Atlas HD base. Turbidity Probe The Turbidity Probe can be […]

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  3. Advanced Applications

    • Prosonix Sonolab SL10 Sonocrystallizer (230V/110V)

      (included)

      The Prosonix Sonolab is a high-performance ultrasound module allowing full control of crystallization processes, for use with the Atlas HD […]

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    • Sonocrystallizer Accessories Pack

      (included)

      The Sonocrystallizer Accessories Pack contains a peristaltic pump, tubing, connectors, and valves for recycling the reactor contents through the Sonolab […]

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  4. Circulation

    • Circulator and Fluid

      (optional)

      Circulator options from industry-leading manufacturer, Huber. A range of circulator accessories and oils for whatever your application are available.

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  5. Dosing

    • Atlas Syringe Pump

      (optional)

      A perfect addition to your lab, the Atlas Syringe Pump and Atlas XL Syringe Pump can be used as standalone syringe […]

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  6. Optional modules

    • Atlas Syringe Pump

      (optional)

      A perfect addition to your lab, the Atlas Syringe Pump and Atlas XL Syringe Pump can be used as standalone syringe […]

      View module details
    • Circulator and Fluid

      (optional)

      Circulator options from industry-leading manufacturer, Huber. A range of circulator accessories and oils for whatever your application are available.

      View module details

Support

These support articles may be helpful for this system