Product used: Asia FLUX

The authors of this publication used the Asia FLUX electrochemistry module to develop a selective oxidative cyclization reaction for diselenide formation and obtained a series of iminoisobenzofurans.

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Product used: Asia FLUX

The author of this publication gives a personal account describing an overview of work conducted to develop flow electrolysis cells and apply these cells in organic electrosynthesis. It highlights the work performed on the Asia FLUX module, including its development.

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Cited product: Asia FLLEX

The adoption of flow technology for the manufacture of chemical entities, and in particular pharmaceuticals, has seen rapid growth over the past two decades with the technology now blurring the lines between chemistry and chemical engineering. Asia FLLEX is cited in this research.

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Product used: Asia FLUX

The authors developed a method for the synthesis of ureas, carbamates through electrochemistry. The common methods make use of phosgene (very dangerous substance) and this new methodology is very easy to be applied on the scaling-up. The Asia FLUX was used for the electrochemical reactions.

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Product used: Asia FLUX

An Asia Flow Chemistry system, including Asia FLUX, was used to perform a sequential oxidation, via heterogeneous biocatalysis, followed by a ciclization, via electrochemistry, to make benzimidazoles compounds. This process was scaled-up and is relevant to green chemistry.

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Product used: Asia FLUX

The use of microfluidics can improve the process of droplet formation while reducing energy consumption. This publication provides an evaluation of an Asia 1 mL microreactor. The authors used Asia pumps, heater, and microreactor to test a model for generating droplets.

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Product used: Asia FLUX

Electrochemical transformations involve complex parameter interactions, ranging from universal chemistry variables such as solvent and reagents to specialist factors including electrode material and current density. Hence, the development of a robust and scale-independent electrochemical reaction can currently be a challenge. This paper features Asia FLUX.

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Product used: Asia FLUX

Electrochemistry, first proposed over two centuries ago, is one of the oldest forms of reaction set-ups explored in a laboratory. Electrochemical methods possess many benefits in comparison with traditional reagent-based transformations, such as (1) innate scalability and sustainability, (2) high functional group tolerance, (3) mild reaction conditions, (4) high versatility and the ability to carry out reactions that were otherwise inaccessible. This paper features Asia FLUX.

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Product used: Asia Syringe Pump

The authors of this paper used the Asia Syringe Pump in their system to transform an opioid compound into an nor-opioid; a N-demethylation reaction.

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Product used: Asia Syringe Pump

In this paper, the researchers used an Asia Syringe Pump to drive solutions into a flow cell to test the influence of temperature in the electrochemistry reactions boron diamond doped electrodes (BDD).

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Product used: Asia FLUX

A paper about C-H bond functionalization using flow processes. C-C bond formation using catalysis. It cites Asia FLUX for the elecrochemical synthesis of pirrolidines.

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Cited product: Asia FLUX

The use of continuous flow conditions for synthetic electrochemical reactions exhibits many benefits over more traditional batch conditions. This is a perspective review about electrochemistry under continuous flow. Syrris are cited as a flow electrochemistry supplier.

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Cited product: Asia FLUX

For more than sixty years, markets and hierarchies have dominated our thinking about economic organization. This paper suggests that a third form, the ecosystem organizational form, has now become so important in practice that it should be accorded equal recognition in theory and in policy-making. Syrris are cited as a flow electrochemistry supplier.

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Product used: Asia FLUX

Review about flow electrosynthesis, focused on the flow cell design as a main driver for selectivity, are of conversion and final yield.

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Cited product: Asia FLUX

A tutorial review about electrochemistry under continuous flow. Syrris are cited as a flow electrochemistry supplier.

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Related product: Asia Photochemistry Reactor

The detailed development of photochemical benzylic brominations using a NaBrO3/HBr bromine generator in continuous flow mode is reported in this paper. Optimization of the bromine generator enables highly efficient mass utilization by HBr recycling, coupled with fast interphase transfer within a microstructured photochemical reactor (405 nm LEDs).

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Product used: Asia FLUX

An efficient and green electrochemical continuous flow approach has been developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2 H ,4 H )-diones through sulfonylation of alkenes under metal-free and oxidant-free conditions. Asia FLUX was used to perform reactions in this research.

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Product used: Asia Syringe Pumps

In this paper, the authors disclosed a visible light photoredox method for the catalytic transfer hydrogenation of diaryl-ketimines. The process utilises triethylamine as a highly economical single source of electron, proton and hydrogen atom. The reaction was characterised by high product yields, fast reaction times and visible light as the solitary energy source. Asia Syringe Pumps were used  was used to perform reactions in this research.

Product used: Asia FLUX

This paper describes the use of electrochemistry to direct amination reactions and the synthesis of a small organic library compound. Asia FLUX was used to perform reactions in this research.

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Cited product: Asia FLUX

A review about the application of electrochemistry on the synthesis of organic compounds. This paper cites Asia FLUX.

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Product used: Asia Flow Chemistry System

The authors of this paper induced a remote halogenation at the position C5 of quinoline compounds using flow photochemistry. They used an Asia Flow Chemistry System in their experiments.

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Product used: Asia FLUX

A review paper about the state-of-art of flow electrochemistry and flow sonochemistry. The Asia FLUX and FRX are cited, including some figures.

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Cited product: Asia FLUX

Organic electrosynthesis is recognized as a green enabling methodology to perform reactions in an efficient and straightforward way. Electrons are used as the reagent to form anionic and cationic radical species from neutral organic molecules, achieving oxidations and reductions and replacing toxic and dangerous reagents. Within this field, the use of microreactors in continuous flow is particularly compatible with electrochemistry because of the convenient advantages of flow over batch.

Asia FLUX is cited in the electrosynthesis chapter of this book.

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Product used: Asia FLUX

Electrosynthesis has much to offer to the synthetic organic chemist. But in order to be widely accepted as a routine procedure in an organic synthesis laboratory, electrosynthesis needs to be presented in a much more user-friendly way. This review paper gives a detailed explanation about the use of electrolysis in organic synthesis and features  Asia FLUX.

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Cited product: Asia FLUX

A short review paper about flow electrosynthesis. Asia FLUX is cited.

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Cited product: Asia FLUX

There is a pressing need to improve overall productivity in the pharmaceutical industry. Judicious investments in chemistry technologies can have a significant impact on cycle times, cost of goods and probability of technical success. This perspective describes some of these technologies developed and implemented at AbbVie, and their applications to the synthesis of novel scaffolds and to parallel synthesis. Asia FLUX is cited in a chapter of this book.

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Cited product: Asia FLUX

This review gives an exhaustive overview of the engineering principles, safety aspects and chemistry associated with liquid phase oxidation in continuous-flow microreactors. Asia FLUX is cited.

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Cited product: Asia FLUX

A flow process for N-Heterocyclic Carbene (NHC)-mediated anodic oxidative amidation of aldehydes is described, employing an undivided microfluidic electrolysis cell to oxidize Breslow intermediates. Asia FLUX is cited in this research.

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Cited product: Asia FLUX

This review describes how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors. In the rapidly changing, multivariant environment of the research laboratory, equipment needs to be modular to accommodate high and low temperatures and pressures, enzymes, multiphase systems, slurries, gases, and organometallic compounds. Asia FLUX is cited in this research.

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Product used: Asia FLUX

In order for microflow electrolysis cells to make their full contribution to routine laboratory organic synthesis, they must be capable of carrying out reactions with good selectivity and high conversion at a high rate of conversion. Asia FLUX was used to to perform electrochemical reactions in this research.

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Product used: Asia FLUX

An expedient synthesis of the indole alkaloid nazlinine is reported in this paper. The researchers used the Asia FLUX module to perform Shono oxidations and generate a small library and Nazlinine.

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Product used: Asia FLUX

In this paper, a continuous-flow microfluidic electrochemical device (Asia FLUX) was designed and evaluated as a practical new laboratory tool to facilitate electrochemical synthetic transformations.

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Product used: Asia FLUX

In vivo, a drug molecule undergoes its first chemical transformation within the liver via CYP450-catalyzed oxidation. The chemical outcome of the first pass hepatic oxidation is key information to any drug development process. Electrochemistry can be used to simulate CYP450 oxidation, yet it is often confined to the analytical scale, hampering product isolation and full characterization.

A very important paper for the drug metabolism, API, and pharma field. Asia FLUX was used for the research.

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Product used: Asia FLUX

A general procedure for the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated electrooxidation of primary and secondary alcohols modified for application in a microfluidic electrolytic cell is described in this paper. Asia FLUX was used to generate TEMPO mediated radicals for alcohol oxidations.

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Product used: Asia FLUX

This paper describes the application development of a high-yielding, high-throughput N-formylpyrrolidine methoxylation reaction carried out in a flow electrochemical cell. Asia FLUX was used to perform reactions in this research.

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