Library synthesis in flow chemistry
The synthesis of a number of analogous compounds for the purposes of testing is often referred to as library synthesis or high-throughput chemistry. The automated Asia system is designed for fast, serial library synthesis in flow chemistry and is capable of synthesizing and purifying 10s – 100s of compounds a day. The heart of Asia is a microfluidic reactor through which reactions are flowed.
With reaction times cut to 2 minutes within the microreactor due to superheating (pseudo-microwave effect), 10s – 100 of compounds can be synthesized and purified a day – with tailored reaction conditions for each synthesis. A liquid handling robot can access a deck of hundreds of compounds which are injected into the flow stream. The Flow Liquid-Liquid EXtraction (FLLEX) module can perform inline aqueous workup before the product is automatically collected by a robot at the output.